Under load, this creates GC pressure that can devastate throughput. The JavaScript engine spends significant time collecting short-lived objects instead of doing useful work. Latency becomes unpredictable as GC pauses interrupt request handling. I've seen SSR workloads where garbage collection accounts for a substantial portion (up to and beyond 50%) of total CPU time per request — time that could be spent actually rendering content.
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Node.js already had its own streaming API at the time that was ported to also work in browsers, but WHATWG chose not to use it as a starting point given that it is chartered to only consider the needs of Web browsers. Server-side runtimes only adopted Web streams later, after Cloudflare Workers and Deno each emerged with first-class Web streams support and cross-runtime compatibility became a priority.